Wound Healing Research. Wound-Be-Gone® Technology.

The Three Stages of Wound Healing

Friday, November 5th, 2010 

Wound healing is a complex mechanism of regaining the original tissues and cellular structures through various cellular, molecular, and vascular events. These events have been divided into different stages of wound healing. There are three main stages of wound healing that are comprised of different sub stages.

The first stage of wound healing is known as inflammatory stage. As the name suggests, an inflammation of the wounded region is seen in this stage. As soon as a person gets injured or wounded, a mechanism of blood clotting starts.


The body first tries to control the bleeding. The process is known as Haemostasis. The blood vessels are shrunk, a process known as vasoconstriction. That results in less supply of blood towards the wounded region. The blood contains higher number of platelets that are responsible for blood clotting.

Once the bleeding is stopped and a scab is formed, the inflammatory phase starts with vasodilatation. Vasodilatation is a mechanism to dilate the blood vessels and the blood supply is increased to the wound. The blood contains white blood cells and growth factors. White blood cells along with neutrophils, macrophages help in fighting against the bacteria, infection and cleanse the wound from debris.

The second stage is the proliferative stage. Angiogenesis occur which is a process of formation of new vascular system to the wound. Epithelialization and granulatory tissue formation are rest of the events that occur in this stage. The inflammatory stage lasts for 2 to 3 days. The proliferative stage starts from the fourth day and remains for four weeks.

Collagen is a protein that is found in connective tissues. The quantity of collagen increases in the tissues which increases the tensile strength of the wound. Collagen and other factors contract the skin. Epithelialization is a process in which a new layer of epithelial cells migrate towards the wounded region. Granulaization tissue is an extra cellular matrix formed of collagen and other cellular matrices. Wound-Be-GoneĀ® provides a moist environment for the healing process to take place.

The third and last stage is the maturation or remodeling stage. Collagen deposition is reduced. The vascular system formed in the proliferative stage is also removed. The wounded area gets shrunk and a scar is formed. Immature collagen is replaced with mature collagen. The tensile strength is the wound is greater at this stage. A scar is formed depending upon the nature of the wound. Some scars remain there forever; some are faded away with the time.


These are the three stages of wound healing. Wound healing is a slow process and is painful as well. Acute wounds take generally less time for healing while chronic wounds take years or a lifetime to heal. These three stages are, though distinct clinically, yet overlap in the wound healing time frame. Application of Wound-Be-GoneĀ® can enhance the speed of the overall healing process. It reduces pain and inflammation and prevents the formation of scar tissue as well.

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