Wound Healing Research. Wound-Be-Gone® Technology.

The process of acute wound healing

Monday, January 24th, 2011 

There are mainly two types of wounds. One is acute wounds and the second is chronic wounds. There is no major difference in the healing mechanism of the two. Acute wounds which are spoiled are known as chronic wounds and require much healing time.

Acute wound healing or repair is a process that consists of replacement of dead or damaged cells by healthy cells. It can also be defined as the replacement of lost tissue by granulation tissue which matures to form scar tissue.

There are certain factors that can affect a normal acute wound healing process. They are known as local factors and systemic factors. Local factors include insufficient blood supply to the wounded area, adhesions to bony surfaces, infections causing agents such as bacteria; movement can cause compression to blood supply and separation of edges of wounds, dehydration, and exposure to radiation and ultraviolet light. There are systemic factors that include age, malnutrition, hormonal disturbance, hematological derangements, poor defense system, and temperature.

There are two different types of acute wound healing. One is healing by primary intention and other is healing by secondary intention. Surgical wounds that require stitching or suturing are often healed by primary intention. The loss of tissue in such acute wounds is the least. The wound is not contaminated with bacteria and the surgical knife causes very few number of underlying skin cells to be damaged. Once the wound is sealed, the open area is filled with blood cells and fibrinogen. Within a day, neutrophils arrive at the area and the epithelial cells gets thicker. After a day or two, macrophages arrive at the site and kill neutrophils. The granulation tissue starts formation. Proliferation of cells occurs. A new network of blood vessels is made available to the wounded area. Collagen starts accumulating which is a protein found in connective tissues. Connective tissue combines the skin edges and forms a scar. In maturation phase, excessive collagen and other mediating cells are removed. The tensile strength is greater at this stage. Wound-Be-GoneĀ® speeds up the primary intention healing process of the wound. It provides a favorable environment for healing to take place.

Another type of healing is healing by secondary intention. Secondary intention healing is suggested for the wounds which cause much loss of body tissue. These wounds include ulcers, abscesses, and larger wounds. The inflammatory stage affects the immediate tissues. Coagulum arrives at the wound area. A few days later, contraction occurs at the site due to arrival of myofibroblasts. New capillary vessels are formed bringing forward different mediators like neutrophils, macrophages and rest of the nutrients. Demolition, acute inflammation, hyperplasia are some of the events taking place in first week of healing. After two weeks granulation tissue formation and collagen accumulation occurs. The rest of the healing process takes months. The regenerated epidermis is thicker and less firm than the original. The scar is first pink and then changes to white after de-vascularization.

No matter what the process of wound healing is, Wound-Be-GoneĀ® surely is of great benefit to the healing process. It speeds up the repair and recovery time while minimizing pain and scarring.

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